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KMID : 1189420070200020089
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Journal of Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology
2007 Volume.20 No. 2 p.89 ~ p.101
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The Effects of Jeondo-san on Anti-Inflammation and Anti-Propionibacterium acnes
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Choi Kwan-Ho
Seo Hyeong-Sik
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Abstract
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Objectives: This study was carried out to investigate the effects of Jeondo-San(JDS) on anti-Inflammation and anti-Propionibacterium acnes.
Methods: The effects of JDS on anti-Inflammation and anti-Propionibacterium acnes were measured by the cytotoxicity of Raw 264.7 cell, the inhibition for NO,TNF-a, PGE₂, iNOS and COX-2, the blocking NF-xB into nucleus and the sterilizing power for Propionibacterium acnes.
Results: 1. All concentrations of JDS has no cytotoxicity in Raw 264.7 cell. 2. All concentrations of JDS inhibited the production of NO in the Raw 264.7 cell stimulated with LPS. 3. All concentrations of JDS did not significantly inhibit the production of TNF-a in the Raw 264.7 cell stimulated with LPS. 4. All concentrations of JDS inhibited the production of PGE₂in the Raw 264.7 cell stimulated with LPS. 5. All concentrations of JDS did not inhibit the expression of COX-2 but concentrations of 50 ug/ml$, 100ug/ml$ JDS inhibited iNOS expression in the Raw 264.7 cell stimulated with LPS. 6. Concentrations of 50 ug/ml, 100 ug/ml JDS has the effect of blocking NF-xB into nucleus in LPS-induced macrophage Raw 264.7 cell. 7. All concentrations of IDS did not have the inhibitory effect of Propionibactrium acnes.
Conclusions: The present date suggest that JDS has a effect on the stage of inflammation of acne.
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KEYWORD
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Jeondo-San, Propionibactriumacnes, NO, TNF-a, iNOS, COX-2, PGE₂, NF-xB
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